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Medicinal Science

Anti-microbial and anti-tumor studies of newly synthesized 2-(4-morpholinyl)-4,6-diarylpyrimidines using nanosized NiO catalytic framework

urn:nbn:sciencein.cbl.2020v7.104

Anti-microbial and anti-tumor studies of newly synthesized 2-(4-morpholinyl)-4,6-diarylpyrimidines using nanosized NiO catalytic framework

Published in Chemical Biology Letters

  • Priyanka Khyaliya Mody University of Science and Technology
  • Ahanthem Priyanca Devi Mody University of Science and Technology
  • Sudesh Kumar Banasthali Vidyapith
  • Ravi Kant Shri Ramswaroop Memorial University
  • Keshav Lalit Ameta Mody University of Science and Technology

Keywords: NiO nanocatalyst, Pyrimidines, Chalcones, Anti-microbial, Anti-tumor

Abstract

A convenient and cost-effective methodology has been developed for the synthesis of some 2-substituted-4,6- diarylpyrimidines through one-pot conversion of various substituted chalcones, S-benzylthiouronium chloride (SBT) and morpholine using NiO nanoparticles as a reusable and economic catalyst. The deployment of this catalyst empowers the synthesis of variety of 2-(4- morpholinyl)-4,6-diarylpyrimidines in improved yields with easy work-up in a relatively short reaction time. The synthesized compounds have been studied for their potential anti-microbial and anti-tumor activities.

Cite as: Khyaliya, P., Devi, A. P., Kumar, S., Kant, R., & Ameta, K. L. (2020). Anti-microbial and anti-tumor studies of newly synthesized 2-(4-morpholinyl)-4,6-diarylpyrimidines using nanosized NiO catalytic framework. Chemical Biology Letters, 7(1), 55-62.

Full text: http://thesciencein.org/journal/index.php/cbl/article/view/104 and http://pubs.iscience.in/journal/index.php/cbl/article/view/972