Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review

Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review


Published in: Journal of Materials NanoScience

  • Parul Pant University of Delhi
  • Dr. Chetna Gupta University of Delhi
  • Sagar Kumar Indian Institute of Science
  • Apoorva Grewal University of Delhi
  • Shivani Garg University of Delhi
  • Aishwarya Rai University of Delhi

Keywords: Silica, Nanoparticles, trumeric, drug delivery, cancer, diabetes, nanomedicine, biomedical science


Silica nanoparticles offer a promising platform for the delivery of drugs, in particular for the drugs which lack water solubility, target capability and have non-specific distribution, systematic toxicity and low therapeutic index. In this review, we focus on the synthesis and therapeutic (particularly, anti-cancer) applications of Curcumin loaded Silica Nanoparticles. Various surface modifications of silica nanoparticles have been discussed that are used to enhance their therapeutic applications. The characterization techniques and study of their biocompatibility have also been presented.

Curcumin Silica Nanoparticles

Cite as: Pant, P., Gupta , C., Kumar, S., Grewal, A., Garg, S., & Rai, A. (2020). Curcumin loaded Silica Nanoparticles and their therapeutic applications: A review. Journal of Materials NanoScience, 7(1), 1-18.

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Contemporary advances in therapeutic portfolio of 2-Azetidinones

Contemporary advances in therapeutic portfolio of 2-Azetidinones


Published in Chemical Biology Letters

  • Rajneesh Kaur Maharishi Markandeshwar (Deemed to be University)
  • Dr. (Mrs.) Raman Singh Maharishi Markandeshwar (Deemed to be University)
  • Priyanka Ahlawat Maharishi Markandeshwar (Deemed to be University)
  • Parul Kaushik Maharishi Markandeshwar (Deemed to be University)
  • Kuldeep Singh Maharishi Markandeshwar University

Keywords: β-lactams, monobactam, antimicrobial drug resistance, biological activity, multi target drugs


The heterocycle moieties form the site of reaction in many enzymes and co-enzymes and also act as an important pharmacophore in the pharmaceutical drug designs. 2-Azetidinones are the 2-carbonyl derivatives of azetidine, more commonly known as β-lactams. These structural entities occupied a central role in the vigil against bacterial infections over the past few decades. A subclass of these heterocyclic systems, monobactams or monocyclic β-lactam derivatives exhibits several biological activities including antibacterial, antifungal, antiprotozoal, anti-mycobacterial, anti-HIV, antiviral, antimalarial, antioxidant, apoptotic inhibitors, anti-inflammatory activity, anticancer activity, herbicidal activity, etc. Monobactams has resistant to the β-lactamase enzyme and could be a reasonable starting point for developing new drugs or inhibitors. In the present review, pharmacological activities of monocyclic β-lactam derivatives have been discussed with respect to current research in the structure-activity relationships in different therapeutic areas.

b-lactam derivatives as drug

Cite as: Rajneesh, K., Singh, R., Ahlawat, P., Kaushik, P., & Singh, K. (2020). Contemporary advances in therapeutic portfolio of 2-Azetidinones. Chemical Biology Letters, 7(1), 13-26.

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Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)

Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)


Published in: Chemical Biology Letters

  • Pooja Mittal University of Delhi
  • Sujata Singh University of Delhi
  • Archana Singh University of Delhi
  • Indrakant K. Singh University of Delhi

Keywords: Drug delivery, Nanomedicine, Nanobiotechnology, Liposome, Nanoparticles, Hydrogels, Aptamer


Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.

Drug delivery system for breast cancer

Cite as: Mittal, P.; Singh, S.; Singh, A.; Singh, I. K. Current Advances in Drug Delivery Systems for Treatment of Triple Negative Breast Cancer (TNBC). Chem Biol Lett 2020, 7(1), 1-12.

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Current Pharmaceutics

Announcing the new journal for pharmaceuticals sciences covering

  • pharmaceutical chemistry,
  • medicinal chemistry,
  • pharmacology,
  • toxicology,
  • drug evaluation,
  • pharmaceutical sciences,
  • drug development,
  • regulatory affairs,
  • drug delivery,
  • clinical studies, and
  • all aspects of pharmaceuticals and therapeutics sciences.

Type: International, Peer review

Start Year: 2020/21

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Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice


Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice

Published in: Chemical Biology Letters

  • Suman Devi Maharshi Dayanand University
  • Jagjeet Singh Maharshi Dayanand University
  • Vijay Kumar Maharshi Dayanand University
  • Vinay Malik Maharshi Dayanand University

Keywords: histopathology, oxidative stress, kidney, lipid peroxidation, toxicology


The present study investigated the effect of monocrotophos, a commonly used organophosphate pesticide exposure in the kidney tissues of the swiss albino mice. Monocrotophos was administered at the sub-lethal doses of 1.25mg/kg, 2.5 mg/kg and 5.0 mg/kg body weight for 24 hr. Monocrotophos toxicity generated oxidative stress in the mice as evidenced by significant decrease in the activities of glutathione, superoxide dismutase and catalase enzymes. The exposure increased the lipid peroxidation and protein oxidation in a dose dependent manner. Oxidative stress generation also elicited cytotoxic effects on the mice kidney which were supported by the histopathological changes like degeneration in glomerulus, bowmen’s capsule and tubules, hemorrhage, mononuclear cell infiltration, tubular cast and congested blood vessels in a dose-dependent manner. In conclusion, the study indicated that monocrotophos exposure at various doses induces significant deleterious health effects in mice kidney tissues via oxidative stress generation.

Cite as: Devi, S., Singh, J., Kumar, V., & Malik, V. (2019). Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice. Chemical Biology Letters, 6(2), 39-45.

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Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity


Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

Published in: Chemical Biology Letters

  • Ashish Bhatt Mewar University
  • Krishna Srivastava Shri Ramswaroop Memorial University
  • Ravi Kant Shri Ramswaroop Memorial University
  • Deepa Lakhmani Shri Ramswaroop Memorial University

Keywords: 4-methyl-1H-isochromen-1-one, 1,1-biphenyl-4,4-diamine, Antibacterial activity, anti-microbial activity


Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.

Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.

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Author Guidelines for International Biomedical Frontiers Journal

Information for Authors for submitting articles to International Biomedical Frontiers Journal

The Authors need to submit a single file containing all the details as described below. The supplementary data files should be submitted as a separate file. A cover letter and graphical abstract should be submitted along with manuscript as details provided below.

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2. B.K. Sharma. Ph.D. Dissertation, Thesis Title, Cornell University, 1995.

3. R. Hussain, D. Shinkoi. Title of book like Synthesis and application of ionic liquid, John Wiley & Sons: New York, 2010.

4. R.S. Buchanod, D.K. Reddy. In Selective Organic Transformations; T.R. Thyagarajan, Ed.; Integrated science: New York, 2002; Vol. 2, pp 1–95.

5. G.L. Loyale, U.S. Patent 5 934 456, 1998; Chem. Abstr. 1998, 65, 2870.

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Authors should mention any conflict of interest in the work submitted to Biomedical Frontiers. The statement about conflict of interest may be mentioned in the ‘Letter to editor’ or placed in the manuscript after acknowledgement section.

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If the manuscript report the experimentation on animals (including clinical trials on human beings), then declaration about ethical way handling of animals and about keeping the complete privacy of human identity (in case of clinical trials) must be mentioned in the manuscript.

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Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3


Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3

Published in Chemical Biology Letters

  • Pooja FNU University of Delhi
  • Nimisha Sinha University of Delhi
  • Sonu Kumar University of Delhi
  • Atul FNU University of Delhi
  • Sumit Kumar University of Delhi
  • Prashant Kumar SRM University
  • Abhishek Pandey University of Delhi
  • Pragya Sharma University of Delhi
  • Vithika Aggarwal University of Delhi
  • Poonam FNU University of Delhi
  • Poonam Mothsra University of Delhi
  • Brajendra Kumar Singh University of Delhi
  • Rishi Pal Singh University of Delhi
  • Yogesh Kumar University of Delhi

Keywords: Apoptotic inducer activity, anti-cancer, anti-tumor, breast cancer, enzyme inhibition, medicinal chemistry


Coumarin, triazoles and thiazolidinones are one of the most preferred and high valued scaffolds frequently used in medicinal chemistry. The synthesis of newly designed coumarin based triazolyl-thiazolidinones was performed and new compounds were obtained in good yields. The listed compounds were evaluated for their apoptotic activity and determined the minimal inhibitory concentrations for each of the compound on SCC-4 cells using MTT viability test. Furthermore, apoptotic inducer activity was assayed by detecting the expression of caspase-3, a key apoptotic enzyme.

Cite as: FNU, P., Sinha, N., Kumar, S., FNU, A., Kumar, S., Kumar, P., Pandey, A., Sharma, P., Aggarwal, V., FNU, P., Mothsra, P., Singh, B., Singh, R., & Kumar, Y. (2019). Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3. Chemical Biology Letters, 6(2), 30-38.

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Design, synthesis and evaluation of Coumarin-Phenylthiazole conjugates as cholinesterase inhibitors

Design, synthesis and evaluation of Coumarin-Phenylthiazole conjugates as cholinesterase inhibitors


Published in Chemical Biology Letters

  • Deepak Mishra Delhi Technological University
  • Atiya Fatima Delhi Technological University
  • Ram Singh Delhi Technological University
  • Nupur S Munjal Jaypee University of Information Technology
  • Vineet Mehta Jaypee University of Information Technology
  • Udayabanu Malairaman Jaypee University of Information Technology

Keywords: Alzheimer’s Disease, Brain disease, medicinal chemistry, coumarin derivative, AChE, BuChE, Nervous system, Neurological


In this paper, we report the design, synthesis, in-silico, and in-vitro evaluations of a series of coumarin-phenylthiazole conjugates to inhibit cholinesterase enzymes. The coumarin and phenylthiazole derivatives have been synthesized separately, and further combined through covalent amine bond linkage. The synthesized compounds showed more inhibition towards BuChE than AChE, where 4-(3-bromophenyl)-1,3-thiazol-2-amine (7i) exhibited the strongest inhibition against BuChE with an IC50 value of 3.54 μM. For the conjugates, 3-{2-[4-(3-nitrophenyl)thiazol-2-ylamino]acetyl}chromen-2-one (8j) exhibited strongest inhibition with an IC50 value of 46.47 μM.  The better inhibition activities towards BuChE are also shown by 3-bromo and 2-fluoro derivatives. It was also observed that the substitution at 3-position, on phenylthiazole moiety produced better results against BuChE than 4-substituted counterparts.

Cite as: Mishra, D., Fatima, A., Singh, R., Munjal, N., Mehta, V., & Malairaman, U. (2019). Design, synthesis and evaluation of Coumarin-Phenylthiazole conjugates as cholinesterase inhibitors. Chemical Biology Letters6(2), 23-30.

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Novel synthesis and Optical investigation of trivalent Europium doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+) nanophosphors for full-color displays


Novel synthesis and Optical investigation of trivalent Europium doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+) nanophosphors for full-color displays

Published in Journal of Materials NanoScience

  • Suman Sheoran M.D. University
  • Sitender Singh M.D. University
  • Ajay Mann M.D. University
  • Anura Samantilleke Universidade of Minho
  • Bernabe Mani Universitat Politecnica de Valencia
  • Devender Singh M.D. University

Keywords: nanophosphors, displays, lanthanide, luminescence, composites, LED


A series of Eu3+ doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+) was synthesized via sol-gel procedure at 950 oC. The optical characteristics of the materials were studied by Photoluminescence (PL) emission spectra. Upon 395 nm excitation and at 0.03 mole concentration of Eu3+ ion, these nanophosphors display optimum photoluminescence with most intense peak due to 5D07F2 (614-616) of dopant. Powder X-ray diffraction (PXRD) analysis proves that all synthesized materials are of crystalline nature and crystallinity improves on increasing temperature. Transmission electron microscopy (TEM) exhibited the spherical shape of particles in 13-30 nm size. Fourier Transformation infrared (FTIR) spectra showed peaks in 400-1000 cm-1 corresponding to gadolinium-oxygen and silicon-oxygen bond vibrations. In BaGd2Si3O10 material, Gd-O vibration is centered at 492 cm-1 and absorption band at 855 cm-1 is result of asymmetric vibrations of SiO in silicate tetrahedral unit. Due to excellent photoluminescence and suitable CIE coordinates, these materials could have brilliant applications in innovative displays.

Research Highlights

  • Series of trivalent europium doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+)fluorescent materials were synthesized successfully with sol-gel procedure.
  • The prepared samples were characterized using Photoluminescence analysis, X-ray diffraction study, Transmission Electron Microscopic analysis and Fourier Transform Infrared spectroscopy.
  • The CIE color coordinates values of phosphor confirmed the red color of complex approving the PL results.
  • X-ray diffraction pattern of these materials determined the particle size using Debye Scherrer’s equation.
  • Excellent photoluminescence response and nano size of these materials made them suitable for various innovative display applications.

Cite as: Sheoran, S., Singh, S., Mann, A., Samantilleke, A., Mani, B., & Singh, D. (2019). Novel synthesis and Optical investigation of trivalent Europium doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+) nanophosphors for full-color displays. Journal of Materials NanoScience, 6(2), 73-81.

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