Nanoparticles in radiopharmaceuticals sciences: Review of the fundamentals, characterization techniques and futures challenges

Authors

  • Sandrine HUCLIER-MARKAI Laboratoire Subatech and GIP ARRONAX
  • Cyrille Alliot GIP ARRONAX
  • Serge Battu Université de Limoges

Keywords:

Drug Delivery, Drug targeting, Imaging, Nuclear Medicine, Nanoparticle Characterization, Field-Flow Fractionation, Nano-PET

Abstract

Nanoparticles are important players in modern medicine, with broad clinical applications ranging from contrast agents in imaging to carriers for drug and gene delivery into tumors. They combine the advantages of multiplexed analytical tools in a single support, offering new possibilities for targeting, sensing and curing pathologies, particularly in nuclear medicine. There is a trend towards integrating the diagnostic and therapeutic functions of nanoparticles, resulting in significantly improved and personalized treatment of disease. Various kinds of nanoparticles for cancer imaging and therapy were engineered since the last decade. For clinical translation, pharmacokinetics and toxicity must be evaluated to meet FDA or Eur. Pharmacopeia requirements. To this aim, a full and exhaustive characterization of these systems must be done such as morphology; chemical composition, surface charge, size and size distribution. The different analytical methods that could fully characterizing nanoparticles are reviewed; together with their advantages, drawbacks and limitations

Nanoradiopharmaceuticals

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Published

2020-07-02

How to Cite

HUCLIER-MARKAI, S., Alliot, C., & Battu, S. (2020). Nanoparticles in radiopharmaceuticals sciences: Review of the fundamentals, characterization techniques and futures challenges. Journal of Materials NanoScience, 7(2), 36-61. Retrieved from http://thesciencein.org/journal/index.php/jmns/article/view/77

Issue

Section

Nanomedicine & Biomaterials

URN