Chemical Biology Letters <p>The Chemical Biology Letters publishes research advances in field of Medicinal Chemistry, Chemistry Biology Interface research, Chemical Biology, Biochemistry, Drug design, development and clincal application advances.</p> en-US <p>Rights and Permission</p> <p>The copyright holder for contents - ScienceIn</p> <p>Permission: The readers can re-use the graphics and images for educational and academic purpose (for reproduction in Review etc) provided that source reference is cited properly.</p> (Editorial, Chem Biol Lett) (Technical Support, ScienceIn) Wed, 13 Jan 2021 06:14:55 +0000 OJS 60 Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air <p>Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and glutathione reductase, were estimated biochemically and the expression of Nrf2 and glutathione peroxidase genes were estimated by reverse transcriptase PCR. Plasma ALT, AST, ALP, MDA and the activity of antioxidant enzymes; SOD, GRd, catalase were found increased significantly in ambient air exposed rats. Ambient air exposure decreased the levels of glutathione, non protein thiols and GPx expression whereas total thiols and expression of Nrf2 increased. However the concurrent administration of astaxanthin was found to reverse these changes in a dose dependent manner. The results of this study revealed the ability of astaxanthin to alleviate liver toxicity and oxidative stress induced by ambient air exposure and points to the possibility of developing astaxanthin as a dietary supplement that reduce the ill effect of toxic chemicals from ambient air.</p> Jasmine Porathoor Johnson, Smitha Renganthan, Aparna Menon, Prof. RG Pillai Copyright (c) 2020 ScienceIn Wed, 13 Jan 2021 00:00:00 +0000 Identification of potential CYP51 inhibiting anti-Aspergillus phytochemicals using molecular docking and ADME/T studies <p>Aspergillosis caused by <em>Aspergillus fumigatus </em>is the second most common pulmonary disease after tuberculosis and recognized as threat to public health in last 2-3 decades. Immunosuppressive action and toxicity of currently available antifungals has necessitated search for new molecules with better efficacy, especially from medicinal plants. In this paper, we screened 1099 phytochemicals from 12 anti-<em>Aspergillus</em> medicinal plants by molecular docking against CYP51 and one best docked molecule from each plant having docking score better than voriconazole was further analysed for ADME/T properties. The best 03 molecules <strong>2</strong>, <strong>3</strong> and <strong>5</strong> from <em>Solanum xanthocarpum</em>, <em>Ocimum sanctum</em> and <em>Argemone Mexicana</em> respectively showed better docking score, lowest blood-brain barrier permeability, high percentage of human oral absorption, good octanol-water partition coefficient and high rate of bioavailability in comparison with other molecules and voriconazole. These molecules may be considered as the best drug leads from this study. The study indicated that the selected molecules may be synthesized and further analyzed for <em>in vitro</em>/<em>in vivo</em> anti-<em>Aspergillus</em> activity to develop effective and safer antifungal drug.</p> Mansi Shrivastava, Poonam Sharma, Rambir Singh Copyright (c) 2021 ScienceIn Publications Wed, 13 Jan 2021 00:00:00 +0000 Regulatory proteins in sperm motility: A review and development of non-hormonal male contraceptives <p>Population studies have revealed that the world population is increasing in an exponential manner and development of low-cost spermicides are the need of day especially in reference to developing countries of Asian Continent where it is a severe problem. Recently, men have expressed willingness to share the burden of family planning. Thus, safe, effective and reversible male contraceptives would satisfy an urgent need among couples. Surgical methods such as vasectomy are currently considered as most of the reliable methods of family planning till-date however acceptance rates is affected mostly due to the need of surgical intervention and the fact that the procedure is considered to be permanent as the successful reversal rate is low. Certain novel sperm motility regulatory proteins have been identified and after continuous experimental evaluation in experimental models has been shown to be have regulatory roles in male fertility and are worthy of being developed as potential contraceptive agents. Present article has been designed to demarcate the cellular and molecular events of those regulatory, anti-motility proteins for assessing their contraceptive efficacy. The intended review besides extending the knowledge in the field of male reproductive endocrinology, may possibly open perspectives for contraceptive development and future application strategies.</p> Arijit Chakraborty Copyright (c) 2020 ScienceIn Wed, 13 Jan 2021 00:00:00 +0000 Gut microbiota based treatment for Diabetes mallitus (T2DM): Challenges and Opportunities <p>Type 2 diabetes&nbsp;mellitus (T2DM) is gradually becoming a major concern worldwide. Due to the various adverse effects of the pharmacological interventions for T2DM, alternative and complementary medicine is being explored for its clinical management. In this review, authors have tried to focus on the role of gut microbiota in preventing and treating T2DM. The mechanistic aspects of the relationship between T2DM and gut microbiota have been explored. There has been lot of research on the role of gut microbiota in regulating human metabolism and various diseases. Various exemplary studies point to a relationship between changes in gut microbiota to T2DM. Therefore, this review has an appraisal of latest research and scope of regulation of gut microbiota with specific focus on T2DM. The therapeutic mechanism of this interaction has also been discussed in detail.</p> Smriti Sharma, Vinayak Bhatia Copyright (c) 2021 ScienceIn Publications Sat, 02 Jan 2021 00:00:00 +0000