Chemical Biology Letters 2020-08-02T13:04:24+00:00 Editorial, Chem Biol Lett Open Journal Systems <p>The Chemical Biology Letters publishes research advances in field of Medicinal Chemistry, Chemistry Biology Interface research, Chemical Biology, Biochemistry, Drug design, development and clincal application advances.</p> Nitazoxanide/Camostat combination for COVID-19: An unexplored potential therapy 2020-08-02T13:04:18+00:00 Manisha Khatri Payal Mago <p>Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lies behind the ongoing outbreak of coronavirus disease 2019 (COVID-19) and its ripple effects has brought major challenges to worldwide health systems. Urgent strategies are required to manage this pandemic and repurposing of existing drugs offer an option forward. A combination drug therapy for COVID-19 aims to prevent both the virus entry/spread as well as quelling the immune system havocs that the virus wreaks in the human body. This article analyzes Nitazoxanide/Camostat combination for their potential activity against SARS-CoV-2. Nitazoxanide, FDA approved drug potentiates host antiviral response, thereby reducing viral replication, titer and ensuing immune dysregulation. Camostat, a potent serine protease inhibitor blocks viral cell entry along with the potential to decrease COVID-19-associated hypercoagulability. Both the drugs do not inhibit cyp P450 enzymes and could be co-administered. Based on the combined pathophysiological and pharmacological potential, the drugs combination potentially recommended for early evaluation and clinical trials of this combination.</p> 2020-07-10T00:00:00+00:00 Copyright (c) 2020 ScienceIn Publishing In silico identification of potent FDA approved drugs against Coronavirus COVID-19 main protease: A drug repurposing approach 2020-08-02T13:04:24+00:00 Vaishali Chandel Sibi Raj Brijesh Rathi Dhruv Kumar <p>The recent outbreak of novel coronavirus disease, COVID-19 has created a threat to human population across the world. The unavailability of specific therapeutics and vaccines, demands the sincere efforts in this direction. Main Proteases of this novel Coronavirus (SARS-CoV-2) play critical role during the disease propagation, and hence represents a crucial target for the drug discovery. Herein, we have applied a bioinformatics approach for drug repurposing to identify the possible potent inhibitors of (SARS-CoV2 Main Proteases. A library of FDA approved antiviral compounds, and active phytochemicals were screened using PyRx virtual screening tool that led to 19 hits based on their highest binding affinity. Nelfinavir exhibited highest binding affinity -8.4 Kcal/mol and strong, stable interactions with the amino acid residues present on the active site of COVID-19 Main Protease. Besides, drugs including Rhein (-8.1), Withanolide D (-7.8), Withaferin A (-7.7), Enoxacin (-7.4), and Aloe-emodin (-7.4) also showed good binding affinity with favorable ADME properties. Our findings suggest that these small molecules can be used as potential inhibitors against COVID-19 Main Protease. However, further investigation and validation of these inhibitors against SARS-CoV-2 are needed to claim their candidacy for clinical trials.</p> 2020-03-27T00:00:00+00:00 Copyright (c) 2020 ScienceIn Publishing Design, synthesis and biological activity evaluation of Carboxylic acid derivatives of substituted 2,3-Diphenyl-2H-1-Benzopyrans as novel selective Estrogen Receptor Modulators 2020-08-02T13:04:21+00:00 Ragini Dubey Ravi Kant Jaya Pandey <p>Synthesis of the molecules that can interact with estrogen receptors (ERs) which show precise manifestation of efficient applications in selective tissue, termed as selective estrogen receptor modulators (SERMs) are of great medicinal significance today. With the problems associated with the selectivity and efficacy of the prevalent estrogen dependent anticancer drugs, the effort continues to evolve more effective SERM compounds. This paper describes the synthesis, biological evaluation and computational studies of a series of novel benzopyrans <strong>(I-III) </strong>to facilitate research in this direction. The evaluation studies revealed that the novel benzopyran analogues exhibit significant antiestrogenic activity when studied on male/female rats of Sprague-Dawley strain and better safety profile on uterus than the most prevalent antibreast cancer drug Tamoxifen. The results demonstrate that the series could produce compounds of alternate therapeutic regimes similar to that of the novel reported compounds of proven prevalent anticancer activities.</p> 2020-06-19T00:00:00+00:00 Copyright (c) 2020 ScienceIn Publishing Current status of Regulatory perspectives on Stem Cell Therapy in India 2020-08-02T13:04:22+00:00 Sandeep Lohmor Ravinder Verma Vinay Malik Deepak Kaushik <p>In the recent decade, regenerative medicines are emerging at fast pace in the field of therapeutics. Regenerative medicines have been used in curing severe diseases; mainly through restoration of stem cells. The stem cells are unspecialized cells which have an infinite proliferation capacity and can differentiate into all type of cells. These properties of stem cells to regenerate the functions of the tissues and organs are used in stem cell therapy. The ability of stem cells to regenerate and reconstruct the damaged tissue makes them an exciting area in medical treatment. Stem cell and stem cell-based products are used in the treatment of many diseases and support therapies. In India, the stem cell and cell-based products are supervised by the Central Drug Standard Control Organization (CDSCO) under the Ministry of Health and Family Welfare. CDSCO regulates the clinical trial approvals, monitoring, and approvals of drug manufacturing or new drugs and marketing authorization of stem cell-based products under the Drugs and Cosmetic Act 1940 and Rules. The focus of the present article is to provide information on the procedure of license approval for stem cells and cells based products in India. The article also include discussion on mandatory requirements of stem cell-based products like manufacturing and process controls, quality control, stability testing, labeling, and quality assurance.</p> 2020-05-01T00:00:00+00:00 Copyright (c) 2020 ScienceIn Publishing