Chemical Biology Letters 2020-01-24T08:53:53+00:00 Editorial, Chemical Biology Letters Open Journal Systems <p>The Chemical Biology Letters publishes research advances in field of Medicinal Chemistry, Chemistry Biology Interface research, Chemical Biology, Biochemistry, Drug design, development and clincal application advances.</p> Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC) 2019-12-28T12:44:10+00:00 Pooja Mittal Sujata Singh Archana Singh Indrakant K. Singh <p>Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.</p> 2019-12-27T00:00:00+00:00 Copyright (c) 2020 ScienceIn Publishing Contemporary advances in therapeutic portfolio of 2-Azetidinones 2020-01-09T14:50:42+00:00 Kaur Rajneesh Raman Singh Priyanka Ahlawat Parul Kaushik Kuldeep Singh <p class="05Abstracttext"><span lang="EN-US">The heterocycle moieties form the site of reaction in many enzymes and co-enzymes and also act as an important pharmacophore in the pharmaceutical drug designs. 2-Azetidinones are the 2-carbonyl derivatives of azetidine, more commonly known as β-lactams. These structural entities occupied a central role in the vigil against bacterial infections over the past few decades. A subclass of these heterocyclic systems, monobactams or monocyclic β-lactam derivatives exhibits several biological activities including antibacterial, antifungal, antiprotozoal, anti-mycobacterial, anti-HIV, antiviral, antimalarial, antioxidant, apoptotic inhibitors, anti-inflammatory activity, anticancer activity, herbicidal activity, etc. Monobactams has resistant to the β-lactamase enzyme and could be a reasonable starting point for developing new drugs or inhibitors. In the present review, pharmacological activities of monocyclic β-lactam derivatives have been discussed with respect to current research in the structure-activity relationships in different therapeutic areas.</span></p> 2020-01-06T15:12:09+00:00 Copyright (c) 2020 ScienceIn Publishing Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents 2020-01-24T08:53:53+00:00 Nidhi Singh Shridhar Satpute Naveen Polkam Ravi Kant Jaya Shree Anireddy Deepa Panhekar Jaya Pandey <p>A library of 28 newer 4<em>H</em>-chromen-4-one derivatives were designed, synthesized and screened for their antibacterial and antifungal efficacy against a panel of bacterial and fungal causative species. Fries and oxa-Michael protocols were employed to achieve the target compound. From the assayed, compounds <strong>5c, 5e, 6a, 7b, 7d, 9a </strong>and<strong> 9b </strong>demonstrated promising anti-bacterial profile whereas products <strong>6a, 7b, 8b </strong>and<strong> 9c </strong>elicited excellent anti-fungal properties. Further, <em>in silico</em> molecular properties were predicted for these sketched analogues to assess their bio availability and drug likeness by using molinspiration software/toolkit. None of them violated Lipinski’s rule of five, signifying them as better anti-bacterial and anti-fungal agents. Both <em>in-silico</em> and biological studies predict derivative <strong>6a </strong>and <strong>7b </strong>as best agent.</p> 2020-01-24T00:00:00+00:00 Copyright (c) 2020 ScienceIn Publishing