Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)

  • Pooja Mittal University of Delhi
  • Sujata Singh University of Delhi
  • Archana Singh University of Delhi
  • Indrakant K. Singh University of Delhi
Keywords: Drug delivery, Nanomedicine, Nanobiotechnology, Liposome, Nanoparticles, Hydrogels, Aptamer

Abstract

Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.

Author Biographies

Pooja Mittal, University of Delhi

Department of Zoology, Deshbandhu College

Sujata Singh, University of Delhi

Deshbandhu College, University of Delhi

Archana Singh, University of Delhi

Hans Raj College, University of Delhi

Indrakant K. Singh, University of Delhi

Deshbandhu College, University of Delhi

drug delivery system for breast cancer
Published
2019-12-27
How to Cite
Mittal, P., Singh, S., Singh, A., & Singh, I. K. (2019). Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC). Chemical Biology Letters, 7(1), 1-12. Retrieved from http://thesciencein.org/journal/index.php/cbl/article/view/96
Section
Review Articles