Radiolabelled nanoparticles in cancer management: current status and developments

Authors

  • Sumeet Suresh Malapure Manipal University
  • Shivanand Bhushan Manipal University
  • Rajesh Kumar Manipal University
  • Sanjay Bharati Manipal University

Keywords:

Nanotechnology, Magnetic nanoparticles, Magnetic hyperthermia, Targeted therapy

Abstract

The current concepts of cancer therapy are moving towards personalized treatment regimen aiming to reduce toxicity and improve efficacy of therapeutic agents. With the development of molecular imaging and targeted therapies personalized care has received a shot in the arm. However, these developments are not without challenges. Drug delivery, metabolism, toxicity etc. challenge the effective utilization of such agents. Nanoparticles offer to overcome these hurdles with their unique physico-chemical properties which can be labeled with radionuclides and conjugated with ligands to achieve high specific activity in the intended areas. In this article, we discuss the present status of radiolabeled nanoparticles, the areas where they are being used and challenges that lie ahead. We intend to provide a basic outlook on the utilization of radiolabeled nanoparticles in cancer diagnosis and therapy.

Author Biographies

Sumeet Suresh Malapure, Manipal University

Kasturba medical college

Shivanand Bhushan, Manipal University

School of Allied Health Sciences

Rajesh Kumar, Manipal University

Kasturba Medical college, School of Allied Health Sciences

Sanjay Bharati, Manipal University

School of Allied Health Sciences

Radiolabelled nanoparticles

Published

2018-01-31

How to Cite

Malapure, S. S., Bhushan, S., Kumar, R., & Bharati, S. (2018). Radiolabelled nanoparticles in cancer management: current status and developments. Chemical Biology Letters, 5(1), 25-34. Retrieved from http://thesciencein.org/journal/index.php/cbl/article/view/42

Issue

Section

Review Articles