1,3,4 Oxadiazole: An emerging scaffold to target different growth factors and kinases

Authors

  • Ankita Bharwal Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy
  • Monika Gupta Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy

Keywords:

kinase inhibitors, Telomerase Inhibitors, Histone deacetylase, Polymerase Inhibitors, Endothelin Antagonists, VEGFR-Inhibitors

Abstract

Five member heterocyclic 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. The important mechanism behind tumor suppression by 1,3,4-Oxadiazole is related with the inhibition of different growth factors, enzymes and kinases etc. The 1,3,4-Oxadiazole scaffold is a five member heterocyclic ring having versatile activities and created interest for synthetic organic and medicinal chemists for the designing of novel compounds having anti- cancer activity. There are great potential in the development of the simple and small 1,3,4-oxadiazole nucleus which is present in various compounds that possess considerable pharmcological properties such as anticancer and aimed to evaluate new products. The main aim of this review article is to highlight the targeted activity of 1,3,4-Oxadiazole derivatives and their structure activity relationship to generate potential anticancer agents.

Oxadiazole kinase inhibitor

Published

2020-10-14

How to Cite

Bharwal, A., & Gupta, M. (2020). 1,3,4 Oxadiazole: An emerging scaffold to target different growth factors and kinases. Chemical Biology Letters, 7(4), 225-235. Retrieved from http://thesciencein.org/journal/index.php/cbl/article/view/120

Issue

Section

Review Articles