Role of Epigenetic Changes in Reproductive Inflammation and Male Infertility

  • Divya Adiga Manipal Academy of Higher Education
  • Sangavi Eswaran Manipal Academy of Higher Education
  • Sriharikrishnaa S Manipal Academy of Higher Education
  • Nadeem Khan G Manipal Academy of Higher Education
  • Shama Prasada Kabekkodu Manipal Academy of Higher Education
Keywords: Spermatogenesis, Epigenetics, Inflammation, Oxidative stress, Male infertility

Abstract

Male infertility is a public health problem affecting one in twenty couples globally. This multifactorial reproductive health issue is a consequence of testicular failure, ejaculatory dysfunction, and altered sperm characteristics caused by a combination of (epi) genetic, environmental, and lifestyle factors. Abnormal epigenetic changes have been proposed as an important causative factor for infertility in men. Abnormal DNA methylation, histone modification, altered non-coding RNAs have been well documented as in pathological conditions such as oligospermia, azoospermia, asthenospermia and tetratospermia in males. Additionally, chronic inflammations in the male genital tract have long been linked with infertility, possibly via affecting the sperm epigenome or its surrounding microenvironment. This review article summarizes the relationship between epigenome, inflammation, and its contribution to male infertility.

Epigenetic led male infertility
Published
2020-03-16
How to Cite
Adiga, D., Eswaran, S., S, S., Khan G, N., & Kabekkodu, S. P. (2020). Role of Epigenetic Changes in Reproductive Inflammation and Male Infertility. Chemical Biology Letters, 7(2), 140-155. Retrieved from http://thesciencein.org/journal/index.php/cbl/article/view/115
Section
Review Articles