Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents

  • Nidhi Singh Amity University Uttar Pradesh
  • Shridhar Satpute Dr. Ambedkar College
  • Naveen Polkam Jawaharlal Nehru Technological University
  • Ravi Kant Shri Ramswaroop Memorial University
  • Jaya Shree Anireddy Jawaharlal Nehru Technological University
  • Deepa Panhekar Dr. Ambedkar College
  • Jaya Pandey Amity University Uttar Pradesh
Keywords: 4H-chromen-4-one, Oxidative Michael addition, in-silico analysis, drug likeness score, Molecular modelling, chromones

Abstract

A library of 28 newer 4H-chromen-4-one derivatives were designed, synthesized and screened for their antibacterial and antifungal efficacy against a panel of bacterial and fungal causative species. Fries and oxa-Michael protocols were employed to achieve the target compound. From the assayed, compounds 5c, 5e, 6a, 7b, 7d, 9a and 9b demonstrated promising anti-bacterial profile whereas products 6a, 7b, 8b and 9c elicited excellent anti-fungal properties. Further, in silico molecular properties were predicted for these sketched analogues to assess their bio availability and drug likeness by using molinspiration software/toolkit. None of them violated Lipinski’s rule of five, signifying them as better anti-bacterial and anti-fungal agents. Both in-silico and biological studies predict derivative 6a and 7b as best agent.

new chromenon derivatives 2020
Published
2020-01-24
How to Cite
Singh, N., Satpute, S., Polkam, N., Kant, R., Anireddy, J. S., Panhekar, D., & Pandey, J. (2020). Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents. Chemical Biology Letters, 7(1), 27-40. Retrieved from http://thesciencein.org/journal/index.php/cbl/article/view/100
Section
Research Articles