Journals Medicinal Science

Immunoendocrine regulation of energy homeostasis and male reproduction

Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.

This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.

Potential topics include but are not limited to the following:

  • Energy homeostasis  and male reproduction
  • Immunoendocrine regulation of male reproductive functions
  • Adipokines and energy metabolism in male fertility
  • Obesity and male infertility: energy imbalance to inflammation
  • Endocrine regulation of epigenetics of reproductive tract inflammation
  • Altered energy metabolism and immune regulation in aged men
Submission Deadline30th June 2021
Publication Date1st Sept 2021

Guest Editors:

Pallav Sengupta, PhD
Department of Physiology
Faculty of Medicine & Biomedical Sciences
MAHSA University
Sulagna Dutta, PhD
Department of Physiology
Faculty of Dentistry
MAHSA University


Article (Research articles and Review Articles) should be submitted online on the journal site as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

There is no publication charges for publishing in special issue or in Chemical Biology Letters.

General Materials Research Medicinal Science

Indian Women Scientists in Material Sciences, NanoSciences and Nanobiotechnology

The Indian Women in Science have shown their matte in past, and continuously have an impactful contribution in the advanced research fields with a notable progress in recent time. In the impression of carved out fields of science, the Women Scientists are achieving worthwhile leading achievements with excellent work in the field of Materials Sciences, NanoSciences and Nanobiotechnology. The editors of Journal of Materials NanoScience have created a special issue to cover the diligent research being conducted by women researchers in India/Indian-abroad in materials science, nanoscience, nanobiotechnology, and related smart materials fields.

The Women Scientists from India/Indian-abroad are invited to publish their research in this special issue towards a perfect collection of reflection of research advances by women researchers in the following fields
* Materials Sciences * NanoScience * Nanotechnology * Nanobiotechnology * Polymer Science * Solar Energy Materials * Smart Chip Materials * Sensors * Energy Storage Materials * Materials Chemistry * Chemistry Nanomaterials * Nanocatalysis * Biomaterials and Nanobiomaterials * Biomedical Engineering Advances * and All allied fundamental to applied field advances.

The first author and/or corresponding author must be women.


  • Open Access : all articles published in this issue will be available freely for download, reading and distribution.
  • No publication charges, No article processing charges, no any other charges of any kind for authors (Platinum open access)
  • The expert fast processing and publishing by the editors.
  • The photograph of first/corresponding author on front cover page on the printed journal issue.
  • Free print copy of the journal to all the corresponding authors.

(An opportunity for recognized research publication, collective information, and possible collaborations in research field)

How to Submit

Prepare your manuscript as per the author guidelines provided for the journal and submit the manuscript online on journal site (in the cover letter mention for consideration of article for special issue)

Submission Date: Submission ongoing

Issue Editor

Dr. Pratima Solanki
Special Centre for Nano Sciences (SCNS)
Jawaharlal Nehru University, (JNU) New Delhi- 110067. India.

Materials Research

Energy Materials – Special issue

New Research Developments in Functional, Nano and Green Energy Materials

Special issue to cover the recent advances in development of Energy Materials is meant to collect research and review articles in following fields

Solar Energy Materials
Perovskite Solar Cells
Battery  and  Energy storage materials
BioEnergy Materials
Green Energy sources developments
Carbon Nanomaterial for Energy
New Chips developments
Nanomaterials development for Energy applications
Chemistry of Energy materials
Fuel Cells 
All other advances in development of Energy materials

Issue Editor:

Dr. B.S. Chhikara, University of Delhi


Submission – Open Now
Issue completion and final publication by March 2021 (Articles published continuously by As-we-go model).

Researchers and Academicians are invited to submit their manuscript on the journal Journal of Materials & NanoScience site as per author guidelines provided on the journal site (article template and other instructions are provided on submission link on journal site).

There is no APC or publication charges for publication of articles in the specials issue.

Journal of Materials NanoScience
Articles General Materials Research Medicinal Science


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Articles Medicinal Science

In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins


In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins

Published in: Chemical Biology Letters


  • Vaishali Chandel Amity University
  • Mitul Srivastava Translational Health Science and Technology Institute
  • Ashutosh Srivastava Amity University
  • Shailendra Asthana Translational Health Science and Technology Institute
  • Dhruv Kumar Amity University Uttar Pradesh, Noida

Keywords: Phytochemicals, Oncoproteins, Molecular docking, Molecular dynamics, simulations


Cancer is the leading cause of mortality worldwide. Conventional chemotherapeutic agents pose a drawback as they are nonspecific. There is an urgent need to identify and design novel targets specific to the tumor. Almost 90,000 species of plants are used as a source of medicines to treat the majority of the disease including cancer. The objective of this study was to understand the interactions between the active phytochemicals selected on the basis of literature review and target oncoproteins in order to find out the biomolecules having strongest bonding actions. Molecular Docking of c-MYC, EGFR and ERBB2 with the selected Phytochemicals showed highest binding energy -7.8 Kcal/mol of EGCG with c-MYC, -8.7 Kcal/mol of Curcumin with EGFR, and -9.4 Kcal/mol of Quercetin with ERBB2. Moreover, molecular dynamics simulation data showed all three phytochemicals exhibits strong stability on their respective targets. Our studies reveal that these three phytochemicals could be promising candidates in designing and optimizing therapeutic strategies against cancer.

molecular modeling of plant drugs

Cite as:

Chandel, V., Srivastava, M., Srivastava, A., Asthana, S., & Kumar, D. (2020). In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins. Chemical Biology Letters, 7(1), 47-54.

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Articles Medicinal Science

Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases


Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases

Anti cancer mechanism of Ziziphus jujube Ber extract

Published in Chemical Biology Letters


  • Radhakrishna G Pillai University of Calicut

Keywords: cancer, proapoptotic genes, phytochemical, diet, HEK293, phytomedicine, anti-cancer nutrients, herbal drugs


Severe side effects as well as the cost of chemotherapy necessitate the need for alternative therapies. Use of plant derived drugs is on the increase for the treatment of various diseases including cancer. This study was designed to explore the effects of the aqueous extract of the ripe fruits of Ziziphus jujube on MCF-7, HCT116 and HEK 293 cell lines to examine the possibility of it being developed as a therapeutic aid in cancer treatment. Cells were exposed to different doses (0-2mg/ml) of the aqueous extract for different time durations ranging from 24h to 72hr. Cell viability and the change in expression of various apoptosis related genes such as Bcl2, Bax, caspase-3 and caspase-9 were studied. Rate of proliferation of the cancer cells (MCF-7 and HCT116) decreased on exposure to the extract in a time and concentration dependent manner. Expression levels of all the genes studied, except Bcl2, showed an increase. Bcl2 expression was inversely proportional to time and concentration of the extract. Levels of activated caspases 3 and 9 were also increased. This report points to the possibility of developing the extract of Ziziphus jujube as a drug for the treatment of cancer.

Cite As:

Pillai, R. G. (2020). Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ratio and through the activation of caspases: Anti cancer mechanism of Ziziphus jujube Ber extract. Chemical Biology Letters, 7(1), 41-46.

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Articles Medicinal Science

Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents


Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents

  • Nidhi Singh Amity University Uttar Pradesh
  • Shridhar Satpute Dr. Ambedkar College
  • Naveen Polkam Jawaharlal Nehru Technological University
  • Ravi Kant Shri Ramswaroop Memorial University
  • Jaya Shree Anireddy Jawaharlal Nehru Technological University
  • Deepa Panhekar Dr. Ambedkar College
  • Jaya Pandey Amity University Uttar Pradesh

Keywords: 4H-chromen-4-one, Oxidative Michael addition, in-silico analysis, drug likeness score, Molecular modelling, chromones


A library of 28 newer 4H-chromen-4-one derivatives were designed, synthesized and screened for their antibacterial and antifungal efficacy against a panel of bacterial and fungal causative species. Fries and oxa-Michael protocols were employed to achieve the target compound. From the assayed, compounds 5c, 5e, 6a, 7b, 7d, 9a and 9b demonstrated promising anti-bacterial profile whereas products 6a, 7b, 8b and 9c elicited excellent anti-fungal properties. Further, in silico molecular properties were predicted for these sketched analogues to assess their bio availability and drug likeness by using molinspiration software/toolkit. None of them violated Lipinski’s rule of five, signifying them as better anti-bacterial and anti-fungal agents. Both in-silico and biological studies predict derivative 6a and 7b as best agent.

Cite as: 1. N. Singh, S. Satpute, N. Polkam, et al. Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents. Chem. Biol. Lett. 2020, 7 (1), 27–40.

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Articles Medicinal Science

Contemporary advances in therapeutic portfolio of 2-Azetidinones


Contemporary advances in therapeutic portfolio of 2-Azetidinones

  • Rajneesh Kaur Maharishi Markandeshwar (Deemed to be University)
  • Dr. (Mrs.) Raman Singh Maharishi Markandeshwar (Deemed to be University)
  • Priyanka Ahlawat Maharishi Markandeshwar (Deemed to be University)
  • Parul Kaushik Maharishi Markandeshwar (Deemed to be University)
  • Kuldeep Singh Maharishi Markandeshwar University

Keywords: β-lactams, monobactam, antimicrobial drug resistance, biological activity, multi target drugs


The heterocycle moieties form the site of reaction in many enzymes and co-enzymes and also act as an important pharmacophore in the pharmaceutical drug designs. 2-Azetidinones are the 2-carbonyl derivatives of azetidine, more commonly known as ?-lactams. These structural entities occupied a central role in the vigil against bacterial infections over the past few decades. A subclass of these heterocyclic systems, monobactams or monocyclic ?-lactam derivatives exhibits several biological activities including antibacterial, antifungal, antiprotozoal, anti-mycobacterial, anti-HIV, antiviral, antimalarial, antioxidant, apoptotic inhibitors, anti-inflammatory activity, anticancer activity, herbicidal activity, etc. Monobactams has resistant to the ?-lactamase enzyme and could be a reasonable starting point for developing new drugs or inhibitors. In the present review, pharmacological activities of monocyclic ?-lactam derivatives have been discussed with respect to current research in the structure-activity relationships in different therapeutic areas.

beta lactams in medicinal research

Cite as: K. Rajneesh, R. Singh, P. Ahlawat, P. Kaushik, K. Singh. Contemporary advances in therapeutic portfolio of 2-Azetidinones. Chem. Biol. Lett. 2020, 7 (1), 13–26.

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Articles Medicinal Science

Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)


Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)

  • Pooja Mittal University of Delhi
  • Sujata Singh University of Delhi
  • Archana Singh University of Delhi
  • Indrakant K. Singh University of Delhi

Keywords: Drug delivery, Nanomedicine, Nanobiotechnology, Liposome, Nanoparticles, Hydrogels, Aptamer


Triple negative breast cancer, the most malignant and aggressive form of breast cancer, is accompanied with poor prognosis in patients. Characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, TNBC cells are unresponsive to hormonal therapy. With only cytotoxic chemotherapy drugs as an established treatment option, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Despite the current advances in TNBC-targeting drug delivery systems (TNBC-TDDS), the treatment outcome remains relatively low. These systems face challenges of drug instability and decreased drug-loading potential. In addition, further investigations are required to address formulations, route of administration, frequency of disease recurrence and non-target side effects, apart from cutting down the cost of development. This concise review summarizes the most recent findings in the field of TNBC-TDDS and highlights the future directions and research perspectives.

Delivery system for Breast cancer

Cite as: P. Mittal, S. Singh, A. Singh, I.K. Singh. Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC). Chem. Biol. Lett. 2020, 7 (1), 1–12..

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General Materials Research Medicinal Science

Nanobiotechnology and Biomaterials in Nuclear Medicine – special issue

Nuclear Medicine, a medical specialty involving the application of radioactive substances and magnetic materials in the diagnosis and treatment of disease have been highly successful in diagnosis of difficult to detect diseases and therapy of various dreaded diseases. Recently, there have been a tremendous research progress in development of newer methods, conjugates and pharmaceuticals for diagnosis and therapy using nanomaterials and nanomedicine approaches in radioactive materials.

The purpose of this special issue proposal is to summarize the recent advances in the field of new NanoMedicinal and Nanobiotechnological advances in development of probes and materials for potential molecular targets and understanding of their mechanism of actions, new radioconjugates development using nanobiomaterials, clinical evaluation and application of new Nano-radiopharmaceuticals, and new techniques/therapy development using Biomaterials. Recent progress will be covered through research articles, review articles and short communications.

The subtopics to be covered in this issue are (though not limited to):

NanoChemistry of new radioactive elements.
– Organic chemistry of Nano-radiopharmaceuticals, chelating agents and standalone Nano-radiopharmaceuticals.
– Progress in SPECT using Nanobiomaterials.
– Progress in Nano-Positron Emission Tomography (nanoPET).
– Application of nanoscience and nanotechnology to Nuclear Medicine.
– Identification of new therapeutic targets.
– Treatment advances of various diseases – cancer, infections, inflammations etc using nano-radiopharmaceuticals.
– Clinical studies and evaluation of nano-radiopharmaceuticals.
– Malarial/mycobacterial/microbial/viral diagnosis and therapy development using nano(bio)materials including biochemical aspects of nano-biomaterials.
– Therapeutic and diagnostic applications of new nano and biomaterials.
– New therapeutic policies and emerging targets for Nuclear nanoMedicine.
– New approaches adopted for the development of nanomedicine of new radiodiagnostic and radiotherapeutic molecules.
– Rational design and drug discovery-Structure-activity relationship (SAR).
NanoDrug Delivery of radiopharmaceuticals – application of different nanobiotechnology conjugates and systems in radiopharmaceuticals.
– Synthetic strategies of new radioactive conjugate molecules.
– Molecular self-assembly as drug delivery carriers of radiopharmaceuticals – Nanotechnology and Biotechnology.
– Environmental aspects, safety measures advances in nuclear medicine.

Provisional Schedule:

Manuscript submission: Submission open and ongoing now.
Issue Completion: October 2020.


Dr. Anil Mishra
Dr. Anil Kumar Mishra
Scientist ‘G’ and Add Director,
Institute of Nuclear Medicine and Allied Science,
DRDO, Timarpur, Delhi. India
Dr. B.S. Chhikara,
University of Delhi
email: drbs @ aditi.

Nuclear and Nano-Medicine researchers are invited to submit their research / review article for this special issue. Manuscript should be prepared and submitted as per author guidelines provided on journal site.

Important Links:

Author Guidelines for preparation of manuscript:

Manuscript template (download): Download template MS word 2007-2010, Citation manager style files and other details are provided in author guidelines section on journal site. section -nanomaterials-materials-nanoscience/

Manuscript Submission: Authors need to submit their manuscript on OR (India-regional site).

There is no fees for publication in special issue or journal.